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Use of colchicine for treatment of gout flare is not recommended in patients receiving the drug for prevention of gout flare and also receiving a cyp3a4 inhibitor.

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Signs and symptoms of colchicine toxicity should be evaluated promptly and, if toxicity is suspected, colchicine capsules should be discontinued immediately.

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it appears, therefore, that colchicine targets a specific step in telomere clustering rather than other changes in nuclear envelope architecture that may accompany or be required for telomere movement.

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